Bupropion was the drug that finally worked to ease my husband’s depression. He tried Effexor and Prozac (zombie) then nothing for years.He started treatment two years ago on Lexapro. He was willing to try drugs again, because the depression got so bad. He decided asked his specialist about Wellbutrin. And this drug has done wonders for his problem, though less helpful on anxiety and Obsessive Compulsive Disorder. But he doesn’t know if he can continue to afford this drug, because the cost of Wellbutrin has steadily increased.